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International Journal of Biological Chemistry
Year: 2015  |  Volume: 9  |  Issue: 1  |  Page No.: 38 - 45

Biochemical Markers of Oxidative Stress in Tissues of Broiler Chickens Fed Zinc Bacitracin and Ascorbic Acid under Hot Climate

I.B. Ismail, K.A. Al- Busadah and S.M. El- Bahr    

Abstract: Previous study demonstrated that, Ascorbic Acid (AA) was more potent than Zinc Bacitracin (ZB) and their combination in increasing levels of serum enzymatic and non-enzymatic antioxidants of broiler chickens reared under hot climate. However, the levels of these enzymes in the tissues of these birds were not estimated earlier. Previously, 200 day old broiler chicks were divided into four treatments; the first treatment (T1), the control was provided with basal diet. Second (T2) and third (T3) treatments were provided with 1 g AA and 100 mg ZB/kg basal diet, respectively. The fourth treatment (T4) was provided with a combination of T2 and T3 for 42 days. At the end of the experiment, liver, heart and kidney tissues were collected and stored frozen until used in the current study for analysis of biochemical markers of oxidative stress. AA and ZB either alone or in combination significantly decreased the lipid peroxidation level (Malondialdehyde; MDA) and increased the activities of glutathione peroxidase (GPx) in all examined tissues compared to the control untreated heat stressed birds. Catalase (CAT), Glutathione-S Transferase (GST) and Glutathione Reductase (GR) activities were only increased in the liver of heat stressed birds treated with AA. However, GST and GR activities were also increased in heart of heat stressed birds treated with either AA or ZB compared to control. In conclusion, AA was more potent than ZB and their combination in increasing the level of enzymatic antioxidants in tissue of heat stressed birds.

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