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International Journal of Biological Chemistry
Year: 2015  |  Volume: 9  |  Issue: 5  |  Page No.: 220 - 234

Green Synthesis of Gold Nanoparticles Using Hypericum hookerianum and its Antiparkinson like Effect in Haloperidol Induced Swiss Albino Mice

S. Subakanmani, S. Murugan and P. Uma Devi    

Abstract: Gold has been used as antidepressants in Indian traditional medicine. Hypericum species are used as alternative to conventional medicines for the treatment of neurodegenerative diseases. The present study focuses on synthesis and characterization of gold nanoparticles (AuNPs) using Hypericum hookerianum and its antiparkinson like effect in haloperidol (1 mg kg–1; ip) induced swiss albino mice. The synthesized AuNPs were characterized by ultraviolet-visible spectroscopy, scanning electron microscopy; energy dispersive X-ray spectrum and fourier transform infrared spectroscopy. The parkinson induced mice were treated with ethanolic extract of H. hookerianum (EEHH) (400 mg kg–1) and H. hookerianum synthesized gold nanoparticles (HHGNps) (40 mg kg–1). Behavioral analyses of mice were examined by rota rod test, gait analysis, wire hang test and their neurobiochemical analysis (dopamine and glutamate) by spectrofluorimetry. In this study, the haloperidol induced group showed depleted dopamine and increased glutamate levels, whereas treated groups exhibited significantly restored values. Among the extracts, EEHH showed well pronounced antiparkinson like effect due to its neuroprotective flavonoids and surprisingly HHGNps treated groups showed greater antiparkinson like effect. The green synthesis of AuNPs showed promising effects for the modern therapeutic era especially with regard to parkinson’s disease.

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