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International Journal of Biological Chemistry
Year: 2012  |  Volume: 6  |  Issue: 2  |  Page No.: 61 - 68

Sucrose Diet Elevates Cardiovascular Risk Factors in Male Albino Rats

B.A. Salau, W.E. Olooto, O.L. Adebayo, E.O. Ajani, K.T. Odufuwa and J.O. Olowookere    

Abstract: Effects of various concentrations of sucrose diet were assessed on thirty weaning male albino rats divided randomly into five equal groups as follows: G1 (baseline group); G2 (control group given rat chow only); G3, G4 and G5 (groups with energy supply from sucrose at 10, 20 and 30%, respectively). The four groups were fed for twelve weeks and then fasted overnight. They were then anaesthetized with diethyl ether and venous blood was collected using cardio puncture method. Plasma was collected by centrifugation and total plasma cholesterol, HDL cholesterol and serum Triglycerides were assayed using Randox enzymatic kit while VLDL cholesterol, LDL cholesterol, Atherogenic index and coronary risk indices were calculated. Sucrose diet increased energy density. It also increased significantly (p<0.05). Plasma total cholesterol, LDL cholesterol, VLDL cholesterol, Triglycerides, Atherogenic and Coronary risk indices while it decreased HDL cholesterol. Present results indicated that sucrose diet at present level of consumption (about 25% energy supply) elevated cardiovascular risk factors in male albino rats and may predispose one to cardiovascular diseases.

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