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International Journal of Biological Chemistry
Year: 2011  |  Volume: 5  |  Issue: 5  |  Page No.: 300 - 313

Protective Effects of Acetyl-L-Carnitine on Subacute Chlorpyrifos-induced Biochemical Changes in Wistar Rats

C. Uchendu, S.F. Ambali, J.O. Ayo, K.A.N. Esievo, I.O. Lasisi and Y.L. Surakat    

Abstract: Induction of oxidative stress is one of the molecular mechanisms involved in chlorpyrifos-induced toxicity. The study was aimed at evaluating the effect of Acetyl-L-Carnitine (ALC), an antioxidant molecule on alterations in biochemical changes evoked by subacute chlorpyrifos (CPF) exposure in Wistar rats. Twenty-eight young adult male Wistar rats used for the study were divided into 4 groups of 7 animals each. Group I was administered S/oil (2 mL kg-1) while group II was given ALC (300 mg kg-1). Group III was administered CPF (8.5 mg kg-1) while group IV was pretreated with ALC (300 mg kg-1) and then administered CPF (8.5 mg kg-1), 30 min later. The regimens were administered orally via gavage for 4 weeks. The sera obtained from the blood samples were analysed for concentrations of electrolytes (Na+, K+, Cl¯ and HCO3¯), total proteins, albumin, globulin glucose, urea, creatinine and activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and creatine kinase. The liver was also examined for malonaldehyde concentration and activities of superoxide dismutase and catalase. The result shows that ALC pretreatments attenuate CPF-evoked alterations in biochemical parameters apparently due to its antioxidant properties.

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