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International Journal of Biological Chemistry
Year: 2010  |  Volume: 4  |  Issue: 1  |  Page No.: 19 - 26

Synthesis and Biological Evaluation of N1-[(3z)-5-Substituted-2-Oxo-1, 2-Dihydro-3H-Indol-3-Ylidene]-5H-Dibenzo [b,f] Azepine-5-Carbohydrazides

K. Ranjit, G.K. Rao and P.N.S. Pai    

Abstract: A novel synthetic methodology of Schiff bases incorporating dibenzazepine carbohydrazide with isatin is described. The title compounds were prepared by condensation of carbohydrazide and substituted isatins. Structures of all these compounds were confirmed by their spectral studies. These compounds were screened for their in vitro antioxidant activity. From the biological studies, it was possible to observe that some of the compounds have shown good antioxidant activity when compared to the standard, ascorbic acid. Compounds with electron withdrawing substitutents (3f) and (3k) have shown better activity at lowest concentration than electron donating substitutents. The ambient conditions, good product yields and easy work up procedures make this methodology a better protocol for the synthesis of newer derivatives which can be explored further for biological activities.

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