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International Journal of Biological Chemistry
Year: 2010  |  Volume: 4  |  Issue: 1  |  Page No.: 1 - 9

Co-Enzyme Q10 Protects Rat Heart against Oxidative Stress Induced by Ischemic Reperfusion Injury

N.A. Khan, P. Chattopadhyay, A. Pawdey, K. Kishore and A.K. Wahi    

Abstract: Oxidative stress plays a major role in the etiopathology of myocardial Ischemic Reperfusion (IR) injury which is a common sequel of ischemic heart disease. Antioxidants have potent therapeutic effects on both ischemic heart disease and ischemic-reperfusion injury. In the present study, the effect of co-enzyme Q10 (CoQ10) on oxidative stress associated with IR injury was investigated in a rat heart model. Eighteen rats of 200-250 g b.wt. were divided into sham-operated control group (I) (n = 6), ischemia and reperfusion group (II) (n = 6) and CoQ10 (1 mg kg-1 b.wt. daily by oral route for 7 days before induced ischemia reperfusion) treated group (III) (n = 6) used for induction of ischemia-reperfusion injury. Hearts from all the groups were then processed for biochemical and histopathological studies. All values were expressed as mean±SD. Differences in mean values were compared using SPSS 11.0 by one-way ANOVA and Student-Newman-Keul (SNK) test. A value of p<0.05 was considered statistically significant. There was a significant increase in myocardial catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities of these enzymes in mitochondria were maintained to near normal (p<0.05) level in CoQ10 treated groups with significant change in group (III) group when compared to group (II). Ischemia and reperfusion induced toxicity reduced remarkable amount of RNA content as compared to sham operated control rat. CoQ10 attenuated decrease DNA and RNA content induced by ischemic and reperfusion. Histopathology studies showed degree of myocardial damage in CoQ10 administered group showing normal structure of myocytes with mild edema during the cardiac IR, which reached a level comparable to sham operated rats. The study strongly suggests that CoQ10 administration prevents oxidative stress and associated ultrastructural changes, induced by myocardial ischemic-reperfusion injury.

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