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International Journal of Biological Chemistry
Year: 2009  |  Volume: 3  |  Issue: 2  |  Page No.: 49 - 55

The Effect of Solvent Extracts of Parimari microphylla on Metabolites of Alloxan-Induced Diabetic Rats

A.P. Igbakin and I.G. Adanlawo    

Abstract: The effect of solvent extracts (ethanol and normal saline) of the seed of Parimari microphylla was investigated on alloxan induced diabetic rats. Rats were administered orally with 500 mg kg-1 body weight of the extracts over a period of five weeks. Plasma glucose, total lipids and cholesterol levels of the animals were monitored throughout the period of the experiment. Also determined were the tissue cholesterol, total lipids, pyruvate and glycogen. The results shows high level of plasma glucose, total lipids and cholesterol i.e., hyperglycemia, hypperlipidemia and hypercholesterolemia, respectively in all the diabetic treated rats except those administered with the ethanolic extract of P. microphylla (EEPM) which reduced the plasma glucose, total lipids and cholesterol of the diabetic animals significantly (p<0.05). Also the elevated tissue pyruvate, total lipids and cholesterol in the diabetic rats were equally reduced significantly (p<0.05) by EEPM and their reduction is favourably compared to that of the control. EEPM increased the reduced tissue glycogen significantly (p<0.05). These results show that the EEPM possesses antidiabetic properties which can normalise all the alterations associated with metabolites in diabetic animals.

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