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International Journal of Biological Chemistry
Year: 2009  |  Volume: 3  |  Issue: 1  |  Page No.: 30 - 34

The Influencing Aspects of Atorvastatin on C-Reactive Protein and Lipid Profile in Patients with Stroke

A. Vijaya Anand, M. Chandrasekharan, S. Kalavathy, K. Uma, M.P. Saravanan, A. Mohamed Saleem Gani, K. Vijaya Kumar, R. Senthil and P. Sampath Kumar    

Abstract: The present study was designed to determine the effects of atorvastatin on C-Reactive Protein (CRP) and lipid profile in patients with stroke, since their anti-inflammatory properties have been investigated recently. Ninety five patients with or without stroke were recruited for the study, of which 60 belongs to control (untreated) and 35 were test group (treated) and received daily with 10 mg day-1 of atorvastatin. The patients were followed for over a period of 3 months. For entire study population, CRP along with lipid profile, Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) were measured 1st day and at the end of 3rd month of the treatment. Treatment with atorvastatin decreases both inflammatory activity and atherogenic lipoproteins. The results of this study will provide important information on how to maximize the therapeutic benefits of atorvastatin in a broader range of patients at risk for cerebrovascular morbidity and mortality.

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