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International Journal of Biological Chemistry
Year: 2009  |  Volume: 3  |  Issue: 3  |  Page No.: 119 - 125

Anti-Oxidant Activity of Piper longum Linn.

S.C. Jagdale, B.S. Kuchekar, A.R. Chabukswar, P.D. Lokhande and C.G. Raut    

Abstract: Myocardial ischemia is a serious cardiac problem which should be diagnosed and treated effectively to prevent its complications. Many plant based medicine have been utilized for the effective treatment in cardiac problems. Myocardial ischemia was induced in rats by administration of isoproterenol. Petroleum ether extract of root and piperine from roots of Piper longum Linn. were subjected for evaluation of their anti-oxidant activity by DPPH scavenging method. Lipid peroxide and Glutathione values in myocardial ischemic rats have also been estimated by inducing myocardial ischemia by using isoproterenol. It has been found that at 50 mg mL-1 concentration pet ether extract and piperine exerts 74.12 and 72.13% of inhibition. Pet ether extract and piperine pretreatment decreases lipid peroxide level and maintain glutathione content to near normal in treated rats. The present study shows that the extract of the root of the plant and piperine exert anti-oxidant activity and are protective in the myocardial ischemic condition.

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