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International Journal of Biological Chemistry
Year: 2008  |  Volume: 2  |  Issue: 2  |  Page No.: 49 - 53

Effects of Cholesterol Feeding Periods on Blood Haematology and Biochemistry of Rabbits

Mohamed Anwar K. Abdelhalim and Hisham A. Alhadlaq    

Abstract: The aim of the present study was investigation of the haematological and biochemical abnormalities in rabbits fed high cholesterol and saturated fat diet for feeding periods of 5, 10 and 15 weeks, i.e., to elucidate changes occurred in blood parameters due to feeding of the diet. For this purpose, forty New Zealand white male rabbits (12 weeks old) were purchased, individually caged and divided into control group (10 rabbits) and cholesterol-fed group (30 rabbits). Blood parameters were Total Cholesterol (TC), Low-Density Lipoprotein Cholesterol (LDLC), High-Density Lipoprotein Cholesterol (HDLC), triglyceride (TG), fibrinogen, haemoglobin, hematocrit, White Blood Cells (WBC), Red Blood Cells (RBC), platelets, lymphocytes, neutrophils, monocytes and eosinophils levels. Control rabbits were subjected to blood analysis at feeding period of 15 weeks. The cholesterol-fed rabbits were subjected to blood analysis at feeding periods of 5, 10 and 15 weeks. The results of the present study indicated that TC, LDLC, HDLC, TG, platelets, fibrinogen levels, WBC and lymphocytes percentage were significantly (p<0.05) increased in cholesterol-fed rabbits as compared with control rabbits. On the contrary, haemoglobin, hematocrit, RBC and neutrophils percentage were significantly (p<0.05) decreased in cholesterol-fed rabbits as compared with control rabbits. However, monocytes and eosinophils percentage were not significantly different in the two groups. The present study demonstrates that blood parameters of rabbits fed high cholesterol and saturated fat diet indicated different changes during the cholesterol feeding periods. Moreover, it became evident that blood parameters may can help in diagnosis and monitoring the progression of atherosclerosis in rabbits fed high cholesterol.

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