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International Journal of Biological Chemistry
Year: 2007  |  Volume: 1  |  Issue: 3  |  Page No.: 168 - 173

The Human Genome and Malaria: Prevalence of Inherited Haemoglobin Disorders in Sokoto, Nigeria

R.A. Umar, S.W. Hassan, M.J. Ladan, I.K. Matazu, M. Nma Jiya and H.O. Usman    

Abstract: Retrospective analysis of the results of haemoglobin genotyping of 1033 cases was conducted at the Haemoglobin Genotyping Laboratory in Sokoto, Nigeria. Haemoglobin genotype determination was performed by cellulose acetate electrophoresis. The results show that 666 (64.5%) were Hb AA, 241 (23.3%) Hb AS, 117 (11.3%) Hb SS, 5.0 (0.48%) Hb AC 2.0 (0.19%) and Hb SC 2.0 (0.19%). We conclude that the prevalence of genes for these haemoglobin variants could be explained on the basis of selection due to evolutionary pressure imposed by malaria in line with malaria theory and theory of balanced polymorphism. The implication of our findings on health care provision and planning in the region is discussed.

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