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International Journal of Biological Chemistry
Year: 2007  |  Volume: 1  |  Issue: 2  |  Page No.: 127 - 130

Fungal Production of Omega-6 Fatty Acid: Gamma-Linolenic Acid

N. Rajendra Goud, Ujjwal Neogi and Ruchi Saumya    

Abstract: The main objectives of this study was to isolate and screening of the fungi for the production of GLA which can be further used to large industrial scale production of GLA from microbial sources. Gamma-linolenic acid, (GLA; cis-6, cis-9, cis-12-octadecatrienoic acid) is an omega-6 fatty acid found in Oenothera biennis, Borago officinalis, Ribes nigrum and fungi mainly in the division Phycomycetes. GLA is extensively used in diabetes, Sjögren's syndrome, osteoporosis, menopausal symptoms, premenstrual syndrome (PMS), allergic rhinitis, rheumatoid arthritis, attention deficit/hyperactivity disorder (ADHD), alcoholism, cancer, weight loss, high blood pressure, heart disease and ulcers. In this study, lipid extraction was carried out by Soxhlet extraction method using petroleum ether (60-80°C). It was found out that the total lipid contents of Cunniinghamella I is more (21.65%) with compared to Mucor II (19.20%) but the GLA content was more (06.34%) in Mucor II. Rhizopus I, Cunniinghamella III, Absidia II, Mucor I strains also had more lipid contents. Stearic acid and oleic acid content was more in all the cases (40-70%). Further the study was carried out using different carbon and nitrogen sources and different physical conditions like different pH, aeration etc to determine the highest yielding conditions with Cunniinghamella I, Rhizopus I, Absidia II and Mucor II. It was found that pH, aeration and C:N ratio played very important role in growth of organism, biomass production and GLA production. In 30:3 C:N ratio, glucose was best carbon source than sucrose because glucose in synthetic media enhances the biomass and the oil contents with compared to 30:6 C:N ratio where the biomass production was more but the oil content was less. In pH 5 the GLA production was more compared to pH 3 and 9. Results of these kind heralds an interesting promise for industrial scale production of GLA from the Phycomycetes.

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