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International Journal of Biological Chemistry
Year: 2007  |  Volume: 1  |  Issue: 1  |  Page No.: 1 - 10

Evaluation of Anti-oxidant Potential of Cleome gynandra L. Leaf Extract on the Components of the Lymphoid Organs in Adjuvant Induced Arthritis in Rats

R.T. Narendhirakannan, S. Subramanian and M. Kandaswamy    

Abstract: In the present study, anti-oxidant effect of ethanolic extract of Cleome gynandra leaves on the components of immune system in adjuvant induced experimental rats was evaluated. Freund’s Complete Adjuvant (FCA) was used to induce arthritis in experimental rats. Levels of Lipid peroxides (LPO) and activities of Superoxide dismutase (SOD), catalase, Glutathione peroxidase (GPx) and reduced glutathione (GSH) were evaluated in the lymphocytes, spleen and thymus of control and experimental rats. Further, the levels of ROS such as, hydroxy radicals, superoxide radicals and hydrogen peroxide (H2O2) were also measured in spleen, thymus and lymphocytes in experimental rats. Paw volume was also measured in the experimental animals. A significant increase in the levels of LPO, ROS and decreased activities of antioxidant enzymes in arthritic rats were observed. The above changes were reverted to near normal in Cleome gynandra leaf extract treated rats. The biologically active compounds such as, terpenes, flavonoids, saponins, steroids, phenolic compounds, alkaloids, carotenes, vitamins, minerals etc., which are present in C. gynandra leaves might be responsible for its anti-oxidant properties. The results demonstrated that anti-oxidant and anti-arthritic potent of C. gynandra leaves.

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