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Glycobiology
Year: 2010  |  Volume: 20  |  Issue: 9  |  Page No.: 1077 - 1088

Helicobacter hepaticus Hh0072 gene encodes a novel {alpha}1-3-fucosyltransferase belonging to CAZy GT11 family

L Zhang, K Lau, J Cheng, H Yu, Y Li, G Sugiarto, S Huang, L Ding, V Thon, P. G Wang and X. Chen    

Abstract:

Lewis x (Lex) and sialyl Lewis x (SLex)-containing glycans play important roles in numerous physiological and pathological processes. The key enzyme for the final step formation of these Lewis antigens is 1-3-fucosyltransferase. Here we report molecular cloning and functional expression of a novel Helicobacter hepaticus 1-3-fucosyltransferase (HhFT1) which shows activity towards both non-sialylated and sialylated Type II oligosaccharide acceptor substrates. It is a promising catalyst for enzymatic and chemoenzymatic synthesis of Lex, sialyl Lex and their derivatives. Unlike all other 1-3/4-fucosyltransferases characterized so far which belong to Carbohydrate Active Enzyme (CAZy, http://www.cazy.org/) glycosyltransferase family GT10, the HhFT1 shares protein sequence homology with 1-2-fucosyltransferases and belongs to CAZy glycosyltransferase family GT11. The HhFT1 is thus the first 1-3-fucosyltransferase identified in the GT11 family.

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