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Genes & Development
Year: 2010  |  Volume: 24  |  Issue: 8  |  Page No.: 738 - 740

Histone acetylation in heterochromatin assembly

J. H Kim and J. L. Workman    

Abstract:

Histone acetylation is generally considered a mark involved in activating gene expression by making chromatin structures less compact. In the April 1, 2010, issue of Genes & Development, Xhemalce and Kouzarides (pp. 647–652) demonstrate that the acetylation of histone H3 at Lys 4 (H3K4) plays a role in the formation of repressive heterochromatin in Schizosaccharomyces pombe. H3K4 acetylation mediates a switch of chromodomain proteins associated with methylated H3K9 during heterochromatin assembly.

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