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Genes & Development

Year: 2009  |  Volume: 23  |  Issue: 20  |  Page No.: 2376 - 2381

Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development

M. A Inlay, D Bhattacharya, D Sahoo, T Serwold, J Seita, H Karsunky, S. K Plevritis, D. L Dill and I. L. Weissman

Abstract

Common lymphoid progenitors (CLPs) clonally produce both B- and T-cell lineages, but have little myeloid potential in vivo. However, some studies claim that the upstream lymphoid-primed multipotent progenitor (LMPP) is the thymic seeding population, and suggest that CLPs are primarily B-cell-restricted. To identify surface proteins that distinguish functional CLPs from B-cell progenitors, we used a new computational method of Mining Developmentally Regulated Genes (MiDReG). We identified Ly6d, which divides CLPs into two distinct populations: one that retains full in vivo lymphoid potential and produces more thymocytes at early timepoints than LMPP, and another that behaves essentially as a B-cell progenitor.

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