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Eastern Mediterranean Health Journal
Year: 2009  |  Volume: 15  |  Issue: 1  |  Page No.: 224 - 229

Study of aerobic granulocyte functional activity in the presence of a radiosensitizer [metronidazole]

Al Krawi E.A.A. and Al Hashimi A.H.M.    

Abstract: The in vitro effects of metronidazole on the production of reactive oxygen species by polymorphonuclear [PMN] cells were studied by means of nitroblue tetrazolium and luminol-dependent chemiluminescence. At therapeutic doses of metronidazole [4.98-24.86 microg/mL] significant inhibition of the production of reactive oxygen species was noted in both methods. The inhibitory effect was in a dose-dependent pattern. The data suggest a scavenging mechanism of metronidazole on reactive oxygen species generated by PMN.

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