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Eastern Mediterranean Health Journal
Year: 2007  |  Volume: 13  |  Issue: 5  |  Page No.: 1181 - 1189

Red cell alloimmunization in sickle-cell anaemia patients

Bashawri L.A.M.    

Abstract: This study in King Fahd Hospital of the University, Saudi Arabia, assessed the frequency of alloimmunization to red cell antigens in sickle-cell anaemia patients over 1996-2004 in order to evaluate the risk of alloimmunization and identify the most common alloantibodies. A retrospective analysis of the transfusion history and medical records of 350 patients aged 2 to 75 years who had received at least 1 transfusion found that 48 patients had developed alloantibodies [13.7%]. The most common alloantibodies detected were: anti-E alone [18.8%], nonspecific [12.5%], inconclusive [12.5%], anti-K [10.4%] and anti-c 3 [6.3%]. Some patients had 1 alloantibody, while others more than 1 and even multiple antibodies. Nine patients had a persistent positive direct antiglobulin test.

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