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Eastern Mediterranean Health Journal
Year: 1999  |  Volume: 5  |  Issue: 3  |  Page No.: 478 - 489

Immunohistochemical detection of p53 protein in ameloblastoma types

El Sissy N.A.    

Abstract: Overexpression of p53 protein in unicystic ameloblastoma [uAB] is denser than in the conventional ameloblastoma [cAB] type, indicating increased wild type p53 - suppressing the growth potential of uAB and denoting the early event of neoplastic transformation, probably of a previous odontogenic cyst. Overexpression of p53 in borderline cAB and malignant ameloblastoma [mAB] types might reflect a mutational p53 protein playing an oncogenic role, promoting tumour growth. Overexpression of p53 protein could be a valid screening method for predicting underlying malignant genetic changes in AB types, through increased frequency of immunoreactive cells or increased staining density.

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