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Eastern Mediterranean Health Journal
Year: 1997  |  Volume: 3  |  Issue: 1  |  Page No.: 58 - 67

In situ characterization of B-and T-lymphocytes in basal cell carcinoma of the head and neck region

Saleh S.M.A., El Sissy A.A. and Ismail E.M.    

Abstract: Twenty cases of basal cell carcinoma [BCC] of the head and neck region were examined immunohistochemically for the detection of T- and Blymphocytes. The results showed that the dense lymphocytic infiltrate surrounding neoplastic cells of BCC consisted chiefly of T-lymphocytes. The lymphocytic infiltrate revealed in parts a pattern of a small lymphocytic follicle with peripherally situated T cells and central B cells. The predominance of Tlymphocytes in BCC suggests a local cell-mediated immune response. However, the presence of B-lymphocytes indicates a possible humoral immune reaction. T cells may be responsible for regulating the proliferation, and thus the growth, of malignant epithelial cells in BCC.

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