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Diabetic Medicine
Year: 2008  |  Volume: 25  |  Issue: 2  |  Page No.: 236 - 238

Reduced frequency of blood group Lewis a-b- in female Type 1 diabetes patients

A. V. Kharagjitsingh, K. Prinsen, H. H. P. J. Lemkes, R. R. P. De Vries, B. O. Roep and K. Buschard    

Abstract: Aims  To examine a disputed association between the Lewis(ab) phenotype and Type 1 diabetes (T1D).

Methods  Lewis red blood cell phenotyping was performed for 97 T1D White patients and 100 control subjects using monoclonal antibodies. Two historical cohorts were also included as a control population.

Results  T1D patients had a lower frequency (4.1%) of Lewis(ab) blood group compared with simultaneously tested healthy control subjects (10.0%) and the historical control group (11.1%, P = 0.02). Male T1D patients showed a Lewis(ab) frequency of 8.0%, which was similar to both matched healthy male donors (9.8%) and historical (9.5%) male control subjects. Unexpectedly, none of the female T1D patients displayed Lewis(ab) phenotype, vs. 10.3% and 10.8% of female control subjects (P = 0.039 and 0.017).

Conclusions  The Lewis(ab) phenotype occurs less frequently in T1D compared with healthy control subjects with a strong female gender bias.

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