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Cancer Prevention Research
Year: 2010  |  Volume: 3  |  Issue: 11  |  Page No.: 1379 - 1381

Breaking the NF-{kappa}B and STAT3 Alliance Inhibits Inflammation and Pancreatic Tumorigenesis

Y. J Surh, A. M Bode and Z. Dong    

Abstract:

This perspective on Liby et al. (beginning on page 1427 in this issue of the journal) discusses the importance of the finding that two synthetic triterpenoids prolonged survival in a pancreatic cancer mouse model. This finding is significant because pancreatic cancer is one of the deadliest human cancers. These compounds inhibited the interaction between NF-B and signal transducer and activator of transcription 3, and determining the mechanisms underlying this inhibition will help to rapidly move these compounds into phase I clinical trials. Cancer Prev Res; 3(11); 1379–81. ©2010 AACR.

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