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Cancer Prevention Research
Year: 2009  |  Volume: 2  |  Issue: 7  |  Page No.: 634 - 640

Chemoprevention of Lung Squamous Cell Carcinoma in Mice by a Mixture of Chinese Herbs

Y Wang, Z Zhang, J. R Garbow, D. J Rowland, R. A Lubet, D Sit, F Law and M. You    

Abstract:

Antitumor B (ATB) is a Chinese herbal mixture of six plants. Previous studies have shown significant chemopreventive efficacy of ATB against human esophageal and lung cancers. We have recently developed a new mouse model for lung squamous cell carcinomas (SCC). In this study, lung SCC mouse model was characterized using small-animal imaging techniques (magnetic resonance imaging and computed tomography). ATB decreased lung SCC significantly (3.1-fold; P < 0.05) and increased lung hyperplastic lesions by 2.4-fold (P < 0.05). This observation suggests that ATB can block hyperplasia from progression to SCC. ATB tissue distribution was determined using matrine as a marker chemical. We found that ATB is rapidly absorbed and then distributes to various tissues including the lung. These results indicate that ATB is a potent chemopreventive agent against the development of mouse lung SCCs.

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