Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Biotechnology
Year: 2014  |  Volume: 13  |  Issue: 5  |  Page No.: 206 - 212

Differences in Mannose-Binding Lectin Gene Polymorphisms in Different Diseases

Mohammad Asgharzadeh and Hossein Samadi Kafil    

Abstract: Mannose-Binding Lectin (MBL) is a member of the collectin family. It binds to various oligosaccharides and activates the classical pathway of complement independent from C1q. The aim of present study is to study the distribution of the alleles of MBL gene and promoter variants in intracellular, extracellular pathogens and autoimmune diseases. Our studies showed occurrence of the codon 54 mutation (allele B) of MBL was associated with the occurrence of the acute hepatitis C, this showed the low MBL level can intense progress of this infection, but in other intracellular infections, low expression MBL genotypes associated with protection against these infections and wild type alleles with high MBL production considered as a risk factor for these intracellular pathogens. In extracellular pathogens, there was contrary and wild types of genotype with high production of MBL were associated with protection against these infections and alleles with low MBL production considered as a risk factor for these pathogens. In autoimmune diseases our study and other studies demonstrated that low MBL was a risk factor for these diseases.

Cited References   |    Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility