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Biotechnology
Year: 2013  |  Volume: 12  |  Issue: 2  |  Page No.: 128 - 134

Antimicrobial Silk Fibroin Hydrogel Instantaneously Induced by Cationic Surfactant

Shan Sun, Fang Zhang, Shanshan Zhang, Tieling Xing and Shenzhou Lu    

Abstract: Current surgical dressings and woundplast have drawbacks such as poor permeability, airtightness and biocompatibility, thus a new material is obligatory to replace the traditional ones. Due to outstanding biocompatibility of Silk Fibroin (SF) and excellent antibacterial properties of Dodecyl Trimethyl Ammonium Bromide (DTAB), a cationic surfactant, the SF/DTAB hydrogel formed instantaneously is recommended. By means of SEM, FTIR and XRD, SF/DTAB hydrogel displayed clustered nanofilaments structure and similar secondary structure and morphology with SF solution mainly consisted of random coils in 1 h, then it tended to be the same as pure SF hydrogel which was composed of porous network structure and primarily contained β-sheet structure. Excellent elasticity and antibacterial effect were verified by rheological and antibacterial measurements.

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