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Year: 2010  |  Volume: 9  |  Issue: 1  |  Page No.: 61 - 66

Chitosan Microparticles Prepared by the Water-in-Oil Emulsion Solvent Diffusion Method for Drug Delivery

T. Phromsopha and Y. Baimark    

Abstract: In the present study biodegradable microparticles of chitosan were prepared by the simple water-in-oil emulsion solvent diffusion method for use as drug delivery systems. Aqueous chitosan solution and ethyl acetate were used as water and oil phases, respectively. Gentamicin sulphate was used as a hydrophilic model drug. Effects of drug content and sodium tripolyphosphate cross-linker on chitosan microparticles and drug release behaviors were investigated. The both drug-free and drug-loaded chitosan microparticles were deflated microparticles and porous structures with 200-400 μm in size. The cross-linking did not affect on microparticle shape and size. The drug release rates decreased as the drug content decreased and the amount of cross-linker increased.

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