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Biotechnology
Year: 2008  |  Volume: 7  |  Issue: 2  |  Page No.: 357 - 359

Cyclosporin Production in Various Solid Substrate Media by Tolypocladium inflatum (ATCC 34921)

A.K. Nisha and K. Ramasamy    

Abstract: Cyclosporins are widely produced through submerged fermentations. Solid state fermentation has been used successfully for the production of enzymes and secondary metabolites. Use of different solid substrate medium for the growth and production of cyclosporin by Tolypocladium inflatum (ATCC 34921) was carried out to increase the cyclosporin yield and to economize the process of production using solid state fermentation. Locally available and cheaper materials like rice bran, wheat bran, rice husk, wheat husk, rice grit, wheat grit, gingili cake, cottonseed cake, groundnut cake, coconut cake and sunflower cake were used. Among the solid substrates included in the study, wheat bran was found to be supportive both in terms of biomass (22 g kg-1) and cyclosporin production (179 mg kg-1).

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