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Year: 2002  |  Volume: 1  |  Issue: 2  |  Page No.: 116 - 120

Sub-acute Toxicity Study of 3,6-Dimethyl-4-Ethyl-O-Acetyl Benzene Isolated from Soil Streptomyces Species

Bytul M. Rahman, M.S.A. Bhuiyan, M. Golam Sadik and A.S.M. Anisuzzman    

Abstract: The sub-acute toxicity study of 3,6-dimethyl-4-ethyl-0-acetyl benzene (BM-5), was carried out on Long Evan’s rats using daily administration (300 μg/rat/day) of compound for 14 consecutive days. Non-significant differences between weight of compound receiving rats and control rats (48±0.816 vs 46±0.816) were found. The change in hematological parameters was found to be nonsignificant (total count of RBC, 5.1±0.081 vs 4.63±0.094; white blood cell, 7.33±0.124 vs 5.73±0.124; platelets, 361666±10274 vs 261666±8498, (cell/ml) x106; percentage of hemoglobin 65.67±1.60 vs 56±0.816; ESR, 25±0.816 vs 19.67±0.471 for experimental and control rats, respectively) and biochemical parameters (serum glutamate pyruvate transaminase, 8.5±0.408 vs 8.33 ±0.471 IU L-1; serum glutamate oxaloacetate transaminase, 9.83±0.235 vs 9.33±0.234 IU L-1; bilirubin, 0.36±0.104 vs 0.34±0.016 μg dL-1; creatinine, 0.67 ±0.089 vs 0.61±0.009 mg dL-1; urea, 18.83±0.235 vs 18.5±0.408 mg dL-1; for experimental and control rats). Therefore, the changes in body weight, hematological and biochemical parameters were statistically non-significant. No detectable abnormalities were found in histopathology of heart, kidney, liver and lung in experimental group of rats as compared with that of the control group of rats.

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