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Archives of Otolaryngology - Head and Neck Surgery
Year: 2009  |  Volume: 135  |  Issue: 9  |  Page No.: 896 - 901

ORIGINAL ARTICLE: Expression of Fibroblast Growth Factor Binding Protein in Head and Neck Cancer

W Li, C Wang, S. K Juhn, F. G Ondrey and J. Lin    

Abstract:

Objectives  To characterize the expression of fibroblast growth factor binding protein (FGF-BP) messenger RNA (mRNA) in head and neck squamous cell carcinoma (HNSCC) and to study the association of FGF-BP with vascularity.

Design  The expression of FGF-BP mRNA in HNSCC was studied in 35 primary and 8 metastatic HNSCC specimens and 7 control tissues using in situ hybridization and reverse transcriptase–polymerase chain reaction (RT-PCR). Microvessels in tumor specimens were identified with endothelial cell markers (von Willebrand factor [vWF] and CD34-specific antibodies). Correlates between FGF-BP and microvessel counts were evaluated statistically.

Setting  University of Minnesota Hospitals and Clinics.

Patients  Forty-two surgically treated patients with HNSCC.

Interventions  The patients were routinely treated in the study hospitals and clinics.

Main Outcome Measures  The expression of FGF-BP and angiogenesis in tumors were evaluated.

Results  In situ hybridization and RT-PCR demonstrated that FGF-BP mRNA transcripts were expressed in 34 of 35 primary HNSCC specimens and 5 of 8 metastatic tumor specimens but not in adjacent control tissues. The microvessel counts in HNSCC specimens were closely related to the expression level of FGF-BP (P < .001).

Conclusion  The expression of FGF-BP is statistically linked to the angiogenesis of HNSCC, suggesting that FGF-BP participates in the angiogenesis of HNSCC.

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