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Applied and Environmental Microbiology
Year: 2008  |  Volume: 74  |  Issue: 20  |  Page No.: 6461 - 6464

Development of a Transposon Mutagenesis System in the Oral Spirochete Treponema denticola

Yu Yang, Philip E. Stewart, Xiaoguang Shi and Chunhao Li    

Abstract: Here, we report successful transposon mutagenesis in the oral spirochete Treponema denticola. A modified Himar1 transposon, including a new antibiotic selection cassette for T. denticola, generated mutations affecting cell division, transport, and chemotaxis, among other processes. This random mutagenesis system should facilitate research on the biology and pathogenesis of this spirochete, which is associated with human periodontal diseases.

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