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Antimicrobial Agents and Chemotherapy

Year: 2008  |  Volume: 52  |  Issue: 8  |  Page No.: 2980 - 2983

Alteration of GyrA Amino Acid Required for Ciprofloxacin Resistance in Klebsiella pneumoniae Isolates in China

Yingmei Fu, Lishuang Guo, Yan Xu, Wenli Zhang, Jiaao Gu, Jianfeng Xu, Xiaobei Chen, Yuehui Zhao, Jiayu Ma, Xinghan Liu and Fengmin Zhang


Resistance to ciprofloxacin was detected in 111 (48.1%) isolates of Klebsiella pneumoniae from China. GyrA alterations were identified in the ciprofloxacin-resistant and ciprofloxacin-susceptible isolates. The results, including previously published data, indicate that the single substitution Ser83→Ile and three types of double mutations at Ser83 and Asp87 were required for ciprofloxacin resistance (P < 0.05).

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