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Alzheimer`s & Dementia
Year: 2010  |  Volume: 6  |  Issue: 3  |  Page No.: 202 - 211

The Alzheimer’s Disease Neuroimaging Initiative: Progress report and future plans

Michael W. Weiner, Paul S. Aisen, Clifford R. Jack Jr., William J. Jagust, John Q. Trojanowski, Leslie Shaw, Andrew J. Saykin, John C. Morris, Nigel Cairns, Laurel A. Beckett, Arthur Toga, Robert Green, Sarah Walter, Holly Soares, Peter Snyder, Eric Siemers, William Potter, Patricia E. Cole and Mark Schmidt    

Abstract: The Alzheimer’s Disease Neuroimaging Initiative (ADNI) beginning in October 2004, is a 6-year research project that studies changes of cognition, function, brain structure and function, and biomarkers in elderly controls, subjects with mild cognitive impairment, and subjects with Alzheimer’s disease (AD). A major goal is to determine and validate MRI, PET images, and cerebrospinal fluid (CSF)/blood biomarkers as predictors and outcomes for use in clinical trials of AD treatments. Structural MRI, FDG PET, C-11 Pittsburgh compound B (PIB) PET, CSF measurements of amyloid β (Aβ) and species of tau, with clinical/cognitive measurements were performed on elderly controls, subjects with mild cognitive impairment, and subjects with AD. Structural MRI shows high rates of brain atrophy, and has high statistical power for determining treatment effects. FDG PET, C-11 Pittsburgh compound B PET, and CSF measurements of Aβ and tau were significant predictors of cognitive decline and brain atrophy. All data are available at UCLA/LONI/ADNI, without embargo. ADNI-like projects started in Australia, Europe, Japan, and Korea. ADNI provides significant new information concerning the progression of AD.

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