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Asian Journal of Scientific Research
Year: 2019  |  Volume: 12  |  Issue: 3  |  Page No.: 323 - 332

Alteration of Serum and Hepatic Trace Element Level in Non-alcoholic Fatty Liver Disease-induced by High-fat Sucrose Diet

Hessah Mohammed Al-Muzafar and Kamal Adel Amin    

Abstract: Background and Objective: Disturbances of trace elements are intricate factors in the progress of obesity and its associated non-alcoholic fatty liver disease (NAFLD), however, the status of these elements has infrequently been studied in NAFLD. The current study aimed to evaluate the iron, zinc, copper, manganese and selenium statuses of serum and liver in control and high-fat sucrose diet-induced non-alcoholic fatty liver disease (NAFLD) as well as their relationships with metabolic risk bio-markers of NAFLD. Material sand Methods: Forty male 1.5-month-old rats were allocated into 2 groups of 20 each. One group was given a standard diet and the second nurtured a high-fat sucrose diet (HFSD) for 16 weeks. Blood was assessed for lipid profile (triglyceride, cholesterol, LDL, HDL) and liver function markers (alanine aminotransferase (ALT) activity). Hepatic histopathology was examined by hematoxylin and eosin (H and E) staining. Serum and hepatic trace element levels were evaluated by means of inductively-coupled plasma mass spectrometry. Results: The HFSD group showed significant changes in lipid profile, increased ALT activity, hepatic small and large fat globule, hepatocyte ballooning and damage indicating induction of NAFLD. Serum iron, zinc, copper and selenium concentrations were significantly decreased and minor serum manganese and selenium levels were observed in the HFSD group compared to the control group. Both hepatic iron and copper levels of the HFSD group surpassed those of the control group. Conclusion: The HFSD-induced NAFLD plays a role in iron homeostasis, thus reducing its bio-availability and increasing its hepatic peak drained from the blood. Furthermore, HFSD-induced NAFLD disturbs serum and hepatic trace elements.

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