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Asian Journal of Scientific Research
Year: 2011  |  Volume: 4  |  Issue: 2  |  Page No.: 149 - 157

Antibacterial Activities of 2-O-butyl-1-O-(2-ethylhexyl) benzene-1,8-dicarboxylate and 1-phenyl-1,4-pentanedione Isolated from Vitellaria paradoxa Root Bark.

S. Garba and L. Salihu    

Abstract: A new antibacterial ester (1), 2-O-butyl-1-O-(2-ethylhexyl) benzene-1,8-dicarboxylate and a ketone (2), 1-phenyl-1,4-pentanedione was isolated from Vitellaria paradoxa (G.Don) heper by directing the fractionation of an ethanol extract of the air dried root bark with bacterial sensitivity assay. The structures of 1 and 2 were determined from 13C-NMR, 1H-NMR, DEPT, IR and GC-MS spectral data. The two compounds were found to be active against gram positive Bacillus subtilis and Staphylococcus aureus and gram negative Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa. The isolation, structural elucidation, NMR spectral assignment and bioactivities of compounds 1 and 2 are reported.

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