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Asian Journal of Scientific Research
Year: 2009  |  Volume: 2  |  Issue: 2  |  Page No.: 87 - 95

Methoxy Poly Ethylene Glycol-b-poly (D, L-lactide-co-glycolide) Films as Drug Delivery Systems for Ibuprofen

Y. Baimark and T. Phromsopha    

Abstract: Methoxy poly (ethylene glycol)-b-poly (D,L-lactide-co-glycolide) diblock copolymers (MPEG-b-PDLLG) films containing a poorly water-soluble drug were prepared by evaporation method of MPEG-b-PDLLG and drug solution in dichloromethane. Ibuprofen was used as a poorly water-insoluble model drug. Influences of MPEG block length and DLL/G ratio on drug-loaded film character and drug release behavior were investigated. Inhibition of entrapped ibuprofen crystallization in the MPEG-b-PDLLG films was observed from thermal analysis. The drug release rates increased as the MPEG block length increased. Incorporation of G units in the PDLL block also induced the faster drug release rate. The drug had released from the films through diffusion mechanism.

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