Study of Antioxidant, Analgesic and Antiulcer Potential of Trichosanthes cucumerina Ethanolic Seeds Extract
The present study was to investigate antioxidant, analgesic
and antiulcer effect of ethanolic seeds extract of Trichosanthes cucumerina.
Extraction was done by cold maceration method for 72 h using ethanol as solvent.
The preliminary phytochemical screening showed the presence of triterpenoids,
flavanoids and sterols. The antioxidant activity was determined by 1,1-diphenyl-2-picrylhydrazyl
(DPPH) radical scavenging method. The extract showed maximum scavenging activity
86.2% at 150 μg mL-1 by DPPH method as compared to standard
antioxidant ascorbic acid. Further extract was studied for antiulcer activity
by ethanol induced ulcer model and Non steroidal anti-inflammatory drugs induced
method and analgesic activity by Eddys
hot plate method. Ethanolic extract of Trichosanthes cucumerina cause
72.1 and 57.1% inhibition of ulcer in Non steroidal anti-inflammatory drugs
induced model and ethanol induced model at 500 mg kg-1. Result concluded
that Ethanolic extract of Trichosanthes cucumerina possess high antiulcer
activity which is due to high antioxidant activity and extract also showed potential
analgesic activity by Eddys
hot plate method.
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