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Asian Journal of Plant Sciences
Year: 2010  |  Volume: 9  |  Issue: 1  |  Page No.: 44 - 50

Cornsilk as a Bioavailable Source of Betasitosterol: A Pharmacokinetic Study Using HPTLC

S. Sarfare, S. Menon and S. Shailajan    

Abstract: Betasitosterol is one of the major phytoconstituents in cornsilk (style and stigma of Zea mays Linn.). This study is an attempt to standardize cornsilk as a bioavailable source of Betasitosterol and it reports the pharmacokinetic evaluation of slurry of cornsilk using HPTLC. The study was conducted on male albino rabbits of New Zealand strain. Blood samples were collected at different time intervals following a single oral administration of cornsilk slurry in water (1 g kg-1 b.wt.). Absorption and elimination of Betasitosterol after ingestion of cornsilk was monitored using changes in the concentration of the marker band in the HPTLC profile. A marker of cornsilk at RF 0.48, identified as Betasitosterol, is detected in rabbit plasma after 1 h of ingestion of the slurry. The marker reaches maximum concentration at 2.5 h post dose and is not detectable in plasma after 24 h. By applying Wagner-Nelson method, it can be deduced that over a 24 h period 32% of Betasitosterol is absorbed when administered in rabbits in the form of slurry of powdered cornsilk. The pharmacokinetic parameters generated, confirm significant bioavailability of Betasitosterol from cornsilk and the potential use of cornsilk as a natural source of Betasitosterol.

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