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The American Journal of Physiology - Cell Physiology
Year: 2010  |  Volume: 298  |  Issue: 3  |  Page No.: 572 - 579

PGC-1{alpha} plays a functional role in exercise-induced mitochondrial biogenesis and angiogenesis but not fiber-type transformation in mouse skeletal muscle

T Geng, P Li, M Okutsu, X Yin, J Kwek, M Zhang and Z. Yan    

Abstract:

Endurance exercise stimulates peroxisome proliferator-activated receptor coactivator-1 (PGC-1) expression in skeletal muscle, and forced expression of PGC-1 changes muscle metabolism and exercise capacity in mice. However, it is unclear if PGC-1 is indispensible for endurance exercise-induced metabolic and contractile adaptations in skeletal muscle. In this study, we showed that endurance exercise-induced expression of mitochondrial enzymes (cytochrome oxidase IV and cytochrome c) and increases of platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31)-positive endothelial cells in skeletal muscle, but not IIb-to-IIa fiber-type transformation, were significantly attenuated in muscle-specific Pgc-1 knockout mice. Interestingly, voluntary running effectively restored the compromised mitochondrial integrity and superoxide dismutase 2 (SOD2) protein expression in skeletal muscle in Pgc-1 knockout mice. Thus, PGC-1 plays a functional role in endurance exercise-induced mitochondrial biogenesis and angiogenesis, but not IIb-to-IIa fiber-type transformation in mouse skeletal muscle, and the improvement of mitochondrial morphology and antioxidant defense in response to endurance exercise may occur independently of PGC-1 function. We conclude that PGC-1 is required for complete skeletal muscle adaptations induced by endurance exercise in mice.

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