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Asian Journal of Mathematics & Statistics

Year: 2014  |  Volume: 7  |  Issue: 1  |  Page No.: 21 - 28

Finite Element Model to Study Effect of Na+/K+ Pump and Na+/Ca2+ Exchanger on Calcium Distribution in Oocytes in Presence of Buffers

Parvaiz Ahmad Naik and Kamal Raj Pardasani


Calcium, a second messenger for signal transduction in cells plays an important role in almost every cell of our human body. In oocytes calcium plays a significant role in oocyte maturation. In the process of reproduction calcium concentration is regulated at high levels in oocytes through various mechanisms so as to meet the requirements of oocytes maturation. Thus modelling of calcium distribution in oocytes can help us in understanding this mechanism in a better way. Here an attempt has been made to develop a finite element model to study calcium distribution in oocytes. The model incorporates the parameters like diffusion coefficient, Na+/K+ pump, Na+/Ca2+ exchanger and buffers like BAPTA and EGTA. The proposed model is solved numerically using appropriate initial and boundary conditions. The program has been developed in MATLAB 7.10 for the entire problem and simulated on a 64 bit machine to compute the numerical results.

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