Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
American Journal of Immunology
Year: 2005  |  Volume: 1  |  Issue: 3  |  Page No.: 96 - 100

Towards Identifying Immunogenic Targets in Visceral Leishmaniasis: Role of 17kDa and 63kDa Phosphoproteins

Shubhankar K Singh, Sanjiva Bimal, Diwakar S Dinesh, Anil K Gupta, Prabhat K Sinha, Raajeeva Bimal and Pradeep Das.    

Abstract: We observed predominant phosphorylation at Protein Kinase C (PKC-α) residue in seven immunoreactive proteins of virulent Leishmania donovani parasites. These phosphoproteins were tested for their ability to stimulate T-cells for secretion of Macrophage Migration Inhibition Factor (MIF) in comparision to crude soluble antigen in Visceral Leishmaniasis (VL) patients. Two of these phosphorylated L. donovani antigens led Leishmania to present these antigens to Th1 cells, which was obvious from an increased MIF response. These phosphorylated antigens i. e. 63kDa and 17kDa further led to reprogramme CD4 cells for enhanced IFN-γ production. The study suggests that PKC-phosphoryalation in L. donovani antigens can play a critical role in modulation of signal transduction pathway in T-cells to differentiate into Th1 effectors.

View Fulltext    |   Related Articles   |   Back
  Related Articles

No Article Found
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility