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American Journal of Food Technology
Year: 2010  |  Volume: 5  |  Issue: 6  |  Page No.: 376 - 384

Studies on Some Biochemical and Histological Changes Associated with Long Term Consumption of Leaves of Ocimum gratissimum L. in Male Rats

E.E.J. Iweala and O. Obidoa    

Abstract: This study investigated changes in some biochemical and histological parameters in male rats fed with an Ocimum gratissimum-supplemented diet for six months. Biochemical parameters studied include serum protein, cholesterol, lipid peroxidation, glutathione-S-transferase, superoxide dismutase, alanine transaminase, aspartate transaminase, alkaline phosphatase, haemoglobin and white blood cells. The histological characteristics of tissue sections of liver, intestines and testes were also examined. The weight of the animals increased significantly (p<0.05) over the control. There were also significant reductions (p<0.05) in serum protein, cholesterol, lipid peroxidation and haemoglobin in the animals. Superoxide dismutase was also significantly increased (p<0.05) while the changes in glutathione-S-transferase, alanine transaminase, aspartate transaminase and alkaline phosphatase were not significant. White blood cell count was significantly increased (p<0.05). Histological changes in the intestines revealed the presence of increased villi and larger globlet cells. The testes also showed increased number of sperm cells and spermatogonia while there were no visible changes in the histology of the liver.

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