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American Journal of Food Technology
Year: 2007  |  Volume: 2  |  Issue: 7  |  Page No.: 618 - 629

Synthesis and Antioxidant Activity of Modified (+)-Catechin Derivatives. Structure-Activity Relationship

Nour-Eddine Es-Safi, Josiane Beauhaire, Christine Le Guerneve and Paul-Henri Ducrot    

Abstract: In a screening program for free radical scavengers, new antioxidant compounds have been obtained by C-8 substitution of various groups on (+)-catechin A ring. Their preparation, purification, identification by MS, 1H and 13C NMR analysis as well as their antiradical/antioxidant properties are reported. In order to explore the substituent effect on the observed activity, the obtained results were compared to that of (+)-catechin. Some of the new compounds were more efficient than the underivatised (+)-catechin as scavengers of 1,1-diphenyl-2-picrylhydrazyl (DPPH°) free radical.

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