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American Journal of Drug Discovery and Development
Year: 2013  |  Volume: 3  |  Issue: 1  |  Page No.: 23 - 31

Effect of Exercise on Lipid Profile and Oxidative Stress in Patients with Type 2 Diabetes Mellitus

R.A. Ngala, Osei Sadique and P.K. Gmagna    

Abstract: Regular physical exercise has been reported to be effective in the prevention or delay of onset of type 2 diabetes, increases insulin sensitivity and ameliorates glucose metabolism and therefore considered beneficial for type 2 diabetes mellitus management. This study investigated the effect of physical exercise on glycaemic control in patients with type 2 diabetes. Overnight fasted blood samples were drawn from the median cubital vein on the anterior forearm of diabetics and the control subjects into plain and fluoride oxalate tubes. The serum from the plain tubes was used to estimate the lipid profile: Blood glucose, serum total cholesterol, triglycerides, low-density lipoproteins, very low-density lipoproteins and high-density lipoproteins were determined using an autoanalyser. The plasma from the fluoridated anticoagulated blood was used to estimate the fasting blood glucose. Malonyldialdehyde level in serum was estimated spectrophotometrically. Anthropometric parameters; height, bodyweight and blood pressures were also measured. Fasting blood glucose was significantly (p<0.05) reduced in the subjects who had longer duration of exercise, triglycerides were significantly (p<0.05) reduced even in mild exercise, whilst HDL was increased (p<0.05) in subjects who did 3 h and over exercise per week. Malonyldialdehyde was significantly (p<0.05) decreased even in moderate exercise. The study demonstrates that exercise modulates fasting blood glucose, lipid profile, oxidative stress in patients with type 2 diabetes and suggest that exercise may have therapeutic, preventative and protective effects on diabetes mellitus and should therefore be used to complement drug therapy.

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