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American Journal of Drug Discovery and Development
Year: 2012  |  Volume: 2  |  Issue: 1  |  Page No.: 32 - 39

Targeting Virulence: Novel Effect of Myristica fragrans on Melanisation and Conidiation of Aspergillus niger

V. Pooja, Hina Sanwal, Seema Bhatnagar and Ashwani K. Srivastava    

Abstract: Myristica fragrans HOUTT has been traditionally used by Asian Indians to treat stomach pains, dysentery, vomiting and the symptoms of malaria. It is also chewed to prevent foul breath. The present study was carried out to elucidate the antifungal effect of four extracts; hexane, chloroform, methanolic and ethanolic extract obtained from Mace. The extracts were concentrated and re-suspended in DMSO. MIC80 was calculated by micro broth dilution method. Results have revealed the extracts to have good antifungal activity against Aspergillus niger and methanol and hexane extracts have been found to be most effective. Methanol and hexane extracts were also associated with de-melanization of Aspergillus niger. Further analysis revealed difference in the structure of the hyphal cell wall of methane and hexane extract treated cells.

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