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American Journal of Drug Discovery and Development
Year: 2012  |  Volume: 2  |  Issue: 1  |  Page No.: 17 - 31

Enhancement of Complexation Efficiency of Meloxicam Using Binary and Ternary Solid Systems: Formulation Considerations

Lokesh Kumar Bhati, Gaurav Tiwari, Ruchi Tiwari and Vijay Kumar    

Abstract: Investigation on binary and ternary systems of β-cyclodextrin (β-CD) and hydroxypropyl-β cyclodextrin (HPβ-CD) with Polyvinylpyrrolidone (PVP) on the solubility of Meloxicam (MX) was studied. Phase solubility analysis with PVP K-30 v was used to investigate interactions in aqueous solution between MX and the carrier, either alone or in combination. Equimolar MX and both CDs solid systems, in the presence or the absence of 0.4% (w/w) PVP, were prepared by kneading, co-evaporation or freeze-drying and characterized by differential scanning calorimetry, X-ray powder diffraction analysis, scanning electron microscopy, infrared spectroscopy and dissolution studies. The combined use of PVP and CDs resulted in a synergistic increasing effect of the aqueous solubility of MX. The phenomenon was interpreted in terms of the strongest complexation capacity of CDs towards MX. The positive effect of PVP K30 also reflected on MX dissolution rates from solid preparations, because all ternary systems, with exception of physical mixtures, dissolved faster than the corresponding MX-CDs binary systems the results of solid state studies accounted for the occurrence of stronger interaction in ternary than in binary systems.

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