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Asian Journal of Biological Sciences
Year: 2020  |  Volume: 13  |  Issue: 1  |  Page No.: 70 - 76

Oral Supplementation of Coconut Oil Attenuates Propanil-induced Oxidative Stress in the Testes of Rats

Chiagoziem Anariochi Otuechere, Oghenetega Jonathan Avwioroko, Simisola Tinuala, Scott Fayemi and Bamidele Adewale Salau    

Abstract: Background and Objective: Pesticides have been implicated in oxidative stress, which is associated with many disorders, including testicular dysfunction. This study, therefore, investigated the ameliorative effect of coconut oil (CCO) on male Wistar rats exposed to propanil (PPN), a commonly used herbicide. Materials and Methods: The study comprised 4 groups of 5 rats each designated as: control, CCO (2.7 mL kg1), PPN (200 mg kg1) and PPN (200 mg kg1) + CCO (2.7 mL kg1). Rats were given their various treatments for 7 days and the ameliorative effect of CCO was assessed using antioxidant indices (superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, reduced glutathione and malondialdehyde levels). Results: The study revealed that PPN exposure significantly (p<0.05) disturbed antioxidant status, increased lipid peroxidation (LPO), alkaline phosphatase (ALP) and acid phosphatase (ACP) levels in testes of rats. Treatment with CCO, however, restored the depleted antioxidant status in rat testes, decreased LPO by 50.4% and reduced ALP activity by 19.6%. Conclusion: The results showed that testicular oxidative stress, a threat to male fertility induced by propanil exposure, could be attenuated by oral supplementation of coconut oil.

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