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Asian Journal of Biological Sciences
Year: 2013  |  Volume: 6  |  Issue: 5  |  Page No.: 265 - 270

Antibodies Against Plasmodium berghei Fraction Inhibit Parasite Propagation in vitro

Monica Nainta and H.S. Banyal    

Abstract: Humoral response exhibited by a fraction of Plasmodium berghei is evaluated in the present study. Immunization of mice with S fraction (supernatant of 20,000 rpm centrifugation) of Plasmodium berghei exhibited high humoral immune response. S fraction contained proteins of molecular weight ranging from 23.15-205.00 kDa. The humoral response was serodiagnostically analyzed employing ELISA, IFA and in vitro invasion inhibition assays. Antimalarial antibodies significantly inhibited invasion of Plasmodium berghei in short-term invasion assay. From the in vitro culture study it was found that S fraction exhibits a high humoral response and sera of five out of ten immunized mice inhibited more than 50% of invasion of erythrocytes by P. berghei.

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