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Asian Journal of Biological Sciences
Year: 2013  |  Volume: 6  |  Issue: 4  |  Page No.: 234 - 238

Protective Effect of Erythrina senegalensis (DC) Leaf Extract on Carbon Tetrachloride-induced Liver Injury in Rats

H.Y. Wakawa and M. Hauwa    

Abstract: The aqueous leaf extract of Erythrina senegalensis (ES) was evaluated for its protective activity against carbon tetrachloride (CCl4)-induced liver injury. A 100, 200 and 400 mg kg-1 b.wt. of the ES leaf extract was administered to different groups of rats for 7 days prior to the CCl4 administration. A significant (p<0.05) decrease was observed in both the groups pretreated with 200 and 400 mg kg-1 b.wt. of the leaf extract on the levels of the enzymes and non enzyme markers of tissue damage, lipid peroxidation and relative organ weights and this is shown to be dose dependant when compared to rats that were given CCl4 only. These results showed that ES possess hepatoprotective principle (s) that was (were) able to prevent the toxicity of CCl4 against the liver of rats.

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