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Asian Journal of Biological Sciences
Year: 2012  |  Volume: 5  |  Issue: 1  |  Page No.: 39 - 45

Fractions Isolated by Differential Centrifugation of Plasmodium berghei Induce Humoral Immune Response

Chhaya Pirta and H.S. Banyal    

Abstract: Plasmodium berghei when subjected to differential centrifugation resulted in various subcellular fractions. Immune sera obtained from mice immunized with PIII fraction (pellet at 24,000 g) showed very high antibody titres detected by ELISA and IFA as compared to other fractions. Mice immunized with these fractions along with placebo controls were also challenged with 1x105 P. berghei infected erythrocytes. Mice immunized with PIII fraction showed complete in vivo protection against parasite. Purification of antigens through immunoadsorption revealed antigens exhibiting protection in vivo against parasite challenge. Such antigens may act as useful tool in a fight against malaria.

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