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Asian Journal of Biological Sciences
Year: 2012  |  Volume: 5  |  Issue: 7  |  Page No.: 365 - 371

Detection of Epstein Barr Virus among Benign and Malignant Breast Tumors

M. Eghbali, M. Ghane, M. Mirinargesi and A. Zare Mehrjardi    

Abstract: Epstein Barr Virus (EBV) infects more than 90% of the world's human population. An association is proposed between EBV infection and occurrence of breast cancer, with a large difference in the results reported by different researchers. This study aimed to investigate the frequency of EBV among benign and malignant breast tumors. A total of 24 carcinomas and 24 fibroadenomas paraffin embedded tumoral tissue samples were obtained from the pathology sections of Toos and Firoozgar hospitals in Tehran, Iran. All samples had been collected from patients from June 2011 to February 2012. DNA was extracted from all samples and their infection with EBV was examined by PCR technique. The results obtained by this study showed that 4 out of 24 carcinoma samples (16.6%) were infected by EBV, while the number of fibroadenoma samples infected by this virus was 1 (4.1%). The frequency of EBV infection was different among malignant and benign tumors. However, no association was observed between EBV infection and the formation of malignant or benign tumors based on the Chi-square test. In relation to some other studies, this analysis does not confirm any association between EBV infection and breast cancer occurrence. However, due to the high frequency of EBV infection among breast cancer patients, future studies are needed to elucidate the possible role of the virus in the disease.

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